Abstract background Background: Neonatal sepsis is a systemic inflammatory reaction against infection that occurs in the first 28 days of life. Neonatal sepsis is one of the main causes of disability and death in the neonatal period all over the world. In the whole world, approximately 1.6 million deaths occur annually due to neonatal sepsis, and 40% of them are in developing countries. Objective: Finding the prevalence of neonatal sepsis among hospitalized babies during the second six months of 1401, who were admitted to Maiwand teaching hospital. Methodology: This research is a descriptive cross-sectional type and was conducted during the second six months of 1401 and using documents of 222 infants admitted to Maiwand teaching hospital. Results: in general, the number of newborns admitted to Maiwand Teaching Hospital during the second six months of 1401 was 222, and the prevalence of neonatal sepsis was found in 194 or 87.39% of newborns. Among these, 105 or 54.12% are male babies, and 89 or 45.88% are female babies. In this research, 28.35% or 55 babies had early sepsis, and 139 or 71.65% had late sepsis. Conclusion: The prevalence of neonatal sepsis in this research was 87.39%, of which 105 or 54.12% were boys, 89 or 45.88% were girls, 55 or 28.35% had early sepsis and 139 or 71.65% had The late sepsis.
 Keywords: neonatal sepsis, prevalence, Maiwand teaching hospital. 

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